Synthesis, characterization and investigation of antioxidant activity of cobalt-quercetin complex

被引：139

作者：

Bukhari, S. Birjees ^{[1
]}

Memon, Shahabuddin ^{[1
]}

Tahir, M. Mahroof ^{[2
]}

Bhanger, M. I. ^{[1
]}

机构：

[1] Univ Sindh, Natl Ctr Excellence Analyt Chem, Jamshoro 76080, Pakistan

[2] St Cloud State Univ, Dept Chem, St Cloud, MN 56301 USA

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2008年 / 892卷 / 1-3期

关键词：

Flavonoids; Antioxidant; Quercetin; Stoichiometry; Co(II) complexation; Spectroscopy;

D O I：

10.1016/j.molstruc.2008.04.050

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This article describes a novel synthesis of cobalt and quercetin center dot 2H(2)O complex in methanol, characterized by using elemental analysis, UV-visible, H-1 NMR, TGA, DSC and IR spectrometric techniques. The formation of complex is deduced from the UV-visible spectra which shows that the successive formation of cobalt-quercetin complex occurs in a ratio of 2:1 (metal/ligand) stoichiometrically. The antioxidant activity of the complex was evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. In this work, we have shown that the metal complexed flavonoids are much more effective free radical scavengers than the free flavonoids. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：39 / 46

页数：8

共 33 条

[1] Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals [J].

Afanas'ev, IB ;

Ostrakhovitch, EA ;

Mikhal'chik, EV ;

Ibragimova, GA ;

Korkina, LG .

BIOCHEMICAL PHARMACOLOGY, 2001, 61 (06) :677-684

[2] Media effects on antioxidant activities of phenols and catechols [J].

Barclay, LRC ;

Edwards, CE ;

Vinqvist, MR .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (26) :6226-6231

[3] Synthesis, structure and antifungal properties of Co(II)-sulfathiazolate complexes [J].

Bellú, S ;

Hure, E ;

Trapé, M ;

Trossero, C ;

Molina, G ;

Drogo, C ;

Williams, PAM ;

Atria, AM ;

Acevedo, JCM ;

Zacchino, S ;

Sortino, M ;

Campagnoli, D ;

Rizzotto, M .

POLYHEDRON, 2005, 24 (04) :501-509

[4]

BORS W, 1990, METHOD ENZYMOL, V186, P343

[5] Conformational and spectroscopic investigation of 3-hydroxyflavone-aluminium chelates [J].

Boudet, AC ;

Cornard, JP ;

Merlin, JC .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2000, 56 (04) :829-839

[6] Metal complexes of the flavonoid quercetin: antibacterial properties [J].

Bravo, A ;

Anacona, JR .

TRANSITION METAL CHEMISTRY, 2001, 26 (1-2) :20-23

[7] Spectroscopic and structural study of complexes of quercetin with Al(III) [J].

Cornard, JP ;

Merlin, JC .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2002, 92 (01) :19-27

[8]

DASILVA JJR, 1997, BIOL CHEM ELEMENTS

[9]

DAVIES BD, 1973, WOOD MECARTY MICROBI

[10] Antioxidant properties of complexes of flavonoids with metal ions [J].

de Souza, RFV ;

De Giovani, WF .

REDOX REPORT, 2004, 9 (02) :97-104

← 1 2 3 4 →