Unusual phenomena during the resolution of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ):: thermodynamic-kinetic control

被引：11

作者：

Bálint, J

Egri, G

Kiss, V

Gajáry, A

Juvancz, Z

Fogassy, E

机构：

[1] Budapest Univ Technol & Econ, Dept Organ Chem Technol, H-1521 Budapest, Hungary

[2] Chinoin Chem & Pharmaceut Works Ltd, H-1325 Budapest, Hungary

[3] VITUKI Plc, H-1095 Budapest, Hungary

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 12卷 / 24期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/S0957-4166(02)00021-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

6-Fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved in several different solvents by tartaric acid derivatives as the most common acidic resolving agents available in industrial quantities. Strong reaction kinetics and solvent dependence were observed, curiously without solvation. In possession of these findings, an economic resolution process is proposed, which is completed by the incorporation of a racemization step. (C)c 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3435 / 3439

页数：5

共 17 条

[1] Synthesis, absolute configuration and intermediates of 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid (flumequine) [J].