Resolution of the flumequine intermediate 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

被引：14

作者：

Bálint, J

Egri, G

Vass, G

Schindler, J

Gajáry, A

Friesz, A

Fogassy, E

机构：

[1] Tech Univ Budapest, Dept Organ Chem Technol, H-1521 Budapest, Hungary

[2] Chinoin Chem & Pharmaceut Works Ltd, H-1325 Budapest, Hungary

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 03期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/S0957-4166(99)00527-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Racemic 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline (FTHQ) was resolved by the N-phthaloyl derivative of the (R)-enantiomer. The enantiomeric mixture was very effectively enriched by recrystallisation from either the melt (working best for mixtures of relatively high starting enantiomeric purities) or from solution of its hydrochloride salt (giving good results when applied for mixtures of moderate to medium enantiomeric purities). (C) 2000 Elsevier Science Ltd, All rights reserved.

引用

页码：809 / 813

页数：5

共 10 条

[1] Synthesis, absolute configuration and intermediates of 9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid (flumequine) [J].