Current Approaches and Challenges in Monitoring Treatment Responses in Breast Cancer

被引:94
作者
Graham, Lindsey J. [1 ]
Shupe, Matthew P. [1 ]
Schneble, Erika J. [1 ]
Flynt, Frederick L. [1 ]
Clemenshaw, Michael N. [1 ]
Kirkpatrick, Aaron D. [1 ]
Gallagher, Chris [2 ]
Nissan, Aviram [3 ]
Henry, Leonard [4 ]
Stojadinovic, Alexander [5 ]
Peoples, George E. [1 ]
Shumway, Nathan M. [1 ]
机构
[1] San Antonio Mil Med Ctr SAMMC, Ft Sam Houston, TX 78234 USA
[2] Walter Reed Natl Mil Med Ctr NMMC, Bethesda, MD 20814 USA
[3] Hadassah Med Ctr, IL-91120 Jerusalem, Israel
[4] IU Hlth Goshen, Goshen, IN 46526 USA
[5] Bon Secours Canc Inst, Richmond, VA 23230 USA
来源
JOURNAL OF CANCER | 2014年 / 5卷 / 01期
关键词
Breast cancer; Treatment monitoring; Future directions; Adjuvant; Neo-adjuvant; Metastatic; CARCINOEMBRYONIC ANTIGEN LEVELS; NEOADJUVANT CHEMOTHERAPY; FOLLOW-UP; CA; 15-3; MAMMOGRAPHIC SURVEILLANCE; MONOCLONAL-ANTIBODY; AXILLARY DISSECTION; AMERICAN SOCIETY; PERSONAL HISTORY; TUMOR-MARKERS;
D O I
10.7150/jca.7047
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Monitoring response to treatment is a key element in the management of breast cancer that involves several different viewpoints from surgery, radiology, and medical oncology. In the adjuvant setting, appropriate surgical and pathological evaluation guides adjuvant treatment and follow up care focuses on detecting recurrent disease with the intention of improving long term survival. In the neoadjuvant setting, assessing response to chemotherapy prior to surgery to include evaluation for pathologic response can provide prognostic information to help guide follow up care. In the metastatic setting, for those undergoing treatment, it is crucial to determine responders versus non-responders in order to help guide treatment decisions. In this review, we present the current guidelines for monitoring treatment response in the adjuvant, neoadjuvant, and metastatic setting. In addition, we also discuss challenges that are faced in each setting.
引用
收藏
页码:58 / 68
页数:11
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