Synthesis of two novel 2-aminocyclopropylidene-1,1-bisphosphonates

被引：7

作者：

Couthon, H ^{[1
]}

Gourvès, JP ^{[1
]}

Guervenou, J ^{[1
]}

Corbel, B ^{[1
]}

Sturtz, G ^{[1
]}

机构：

[1] UFR Sci, Lab Chim Heteroorgan, F-29285 Brest, France

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 23期

关键词：

D O I：

10.1080/00397919908085898

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of tetraethyl aminocyclopropylidene-1,1-bisphosphonate 1 and tetraethyl 2-(aminomethyl)cyclopropylidene-1,1-bisphosphonate 2 are described. The key steps include Michael addition, cyclisation and Curtius reaction for compound 1 and cyclisation, azide nucleophilic substitution and Staudinger reaction for 2.

引用

页码：4251 / 4260

页数：10

共 19 条

[1]

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[2]

COUTHON H, 1993, CR ACAD SCI II-MEC P, V316, P181

[3] SYNTHESIS OF ETHENYLIDENEBIS(PHOSPHONIC ACID) AND ITS TETRAALKYL ESTERS [J].