Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome

被引：36

作者：

Carroll, Jessica ^{[1
]}

Saxena, Richa ^{[2
,3
]}

Welt, Corrine K. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Reprod Endocrine Unit, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Dept Anesthesia, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2012年 / 25卷 / 5-6期

关键词：

birth weight; body mass index (BMI); breastfeeding; puberty; GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; YOUNGER WOMEN; ADMIXTURE MAP; BIRTH-WEIGHT; ADULTHOOD; GROWTH; LOCI; HISTORY; OBESITY;

D O I：

10.1515/jpem-2012-0047

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: We hypothesized that body mass index (BMI) and DNA variants would predict age at menarche in polycystic ovarian syndrome (PCOS). Subjects: Subjects aged 18-45 years with PCOS defined by the National Institutes of Health criteria (n=522) and controls with regular menstrual cycles and no hyperandrogenism (n=472) were studied. Methods: Age at menarche was compared between PCOS cases and controls and examined as a function of multiple parameters. Results: There was a strong inverse relationship between BMI and age at menarche in PCOS (r=-0.32, p=5x10(-11)). The chromosome 6 rs7759938-T variant was associated with earlier age at menarche in women with PCOS (12.60 +/- 0.09 vs. 13.41 +/- 0.23 years; genotype TT vs. CC; p=0.006). Age at menarche was predicted by PCOS status (beta=0.512, p<0.001), reported weight group at 10-14 years (beta=-0.432, p<0.001), current BMI (beta=-0.0202, p=0.01), and genotype (beta=0.169, p=0.02). Conclusions: Age at menarche in women with PCOS is influenced by BMI and genetic variants near LIN28B

引用

页码：459 / 466

页数：8

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