Reorganization in primary motor cortex of primates with long-standing therapeutic amputations

被引:115
作者
Wu, CWH [1 ]
Kaas, JH [1 ]
机构
[1] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA
关键词
plasticity; microstimulation; frontal lobe; somatosensory cortex; monkeys; prosimians;
D O I
10.1523/JNEUROSCI.19-17-07679.1999
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Intracortical microstimulation was used to investigate the organization of primate primary motor cortex (M1) in three squirrel monkeys and two galagos years after the therapeutic amputation of an injured forelimb or hindlimb. In two squirrel monkeys with forelimb amputation, physiological results were correlated with the distribution of corticospinal neurons after injections of tracers into the lower cervical segments of the spinal cord. Distributions of labeled corticospinal neurons helped identify the locations of the former forelimb cortex in M1. Evoked movements from M1 ipsilateral to the missing limb were not obviously different from M1 of normal controls. Stimulation in the deefferented part of M1 contralateral to the missing limb elicited movements of the remaining proximal muscles as well as movements from adjacent body representations in all cases. Stimulation in the deefferented forelimb cortex evoked shoulder stump, trunk, and orofacial movements, whereas stimulation in the deefferented hindlimb cortex evoked hip stump, trunk, and tail movements. Movements were evoked from all sites in the deprived cortex, so that there were no unresponsive zones. Minimal levels of current necessary to evoke these movements varied from those in the normal range to those of much higher levels, with the average threshold higher than normal. Finally, multiunit recording from the two galagos revealed that the deprived portions of S1 were responsive to touch or taps on the stump and neighboring body parts.
引用
收藏
页码:7679 / 7697
页数:19
相关论文
共 87 条
[31]   REDUCTION IN NUMBER OF IMMUNOSTAINED GABAERGIC NEURONS IN DEPRIVED-EYE DOMINANCE COLUMNS OF MONKEY AREA-17 [J].
HENDRY, SHC ;
JONES, EG .
NATURE, 1986, 320 (6064) :750-753
[32]   LONG-TERM POTENTIATION OF HORIZONTAL CONNECTIONS PROVIDES A MECHANISM TO REORGANIZE CORTICAL MOTOR MAPS [J].
HESS, G ;
DONOGHUE, JP .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 71 (06) :2543-2547
[33]   Conditions for the induction of long-term potentiation in layer II/III horizontal connections of the rat motor cortex [J].
Hess, G ;
Aizenman, CD ;
Donoghue, JP .
JOURNAL OF NEUROPHYSIOLOGY, 1996, 75 (05) :1765-1778
[34]   FRONTAL EYE FIELD AS DEFINED BY INTRACORTICAL MICROSTIMULATION IN SQUIRREL-MONKEYS, OWL MONKEYS, AND MACAQUE MONKEYS .1. SUBCORTICAL CONNECTIONS [J].
HUERTA, MF ;
KRUBITZER, LA ;
KAAS, JH .
JOURNAL OF COMPARATIVE NEUROLOGY, 1986, 253 (04) :415-439
[35]   RELATIONSHIP OF INTRINSIC CONNECTIONS TO FORELIMB MOVEMENT REPRESENTATIONS IN MONKEY MOTOR CORTEX - A CORRELATIVE ANATOMIC AND PHYSIOLOGICAL STUDY [J].
HUNTLEY, GW ;
JONES, EG .
JOURNAL OF NEUROPHYSIOLOGY, 1991, 66 (02) :390-413
[36]   Correlation between patterns of horizontal connectivity and the extent of short-term representational plasticity in rat motor cortex [J].
Huntley, GW .
CEREBRAL CORTEX, 1997, 7 (02) :143-156
[37]  
HUNTSMAN MM, 1994, J NEUROSCI, V14, P2236
[38]   RESHAPING THE CORTICAL MOTOR MAP BY UNMASKING LATENT INTRACORTICAL CONNECTIONS [J].
JACOBS, KM ;
DONOGHUE, JP .
SCIENCE, 1991, 251 (4996) :944-947
[39]   Deactivation and reactivation of somatosensory cortex after dorsal spinal cord injury [J].
Jain, N ;
Catania, KC ;
Kaas, JH .
NATURE, 1997, 386 (6624) :495-498
[40]   MOTOR ORGANIZATION OF THE SPINAL ACCESSORY NERVE IN THE MONKEY [J].
JENNY, A ;
SMITH, J ;
DECKER, J .
BRAIN RESEARCH, 1988, 441 (1-2) :352-356