Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

被引：41

作者：

Pitts, WJ ^{[1
]}

Vaccaro, W ^{[1
]}

Huynh, T ^{[1
]}

Leftheris, K ^{[1
]}

Roberge, JY ^{[1
]}

Barbosa, J ^{[1
]}

Guo, JQ ^{[1
]}

Brown, B ^{[1
]}

Watson, A ^{[1
]}

Donaldson, K ^{[1
]}

Starling, GC ^{[1
]}

Kiener, PA ^{[1
]}

Poss, MA ^{[1
]}

Dodd, JH ^{[1
]}

Barrish, JC ^{[1
]}

机构：

[1] Bristol Myers Squibb Pharmaceut Res Inst, Princeton, NJ 08543 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 11期

关键词：

D O I：

10.1016/j.bmcl.2004.03.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity relationships (SAR), and selectivity against several other PDE family members are described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2955 / 2958

页数：4

共 16 条

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