Derivatization in mass spectrometry-3. Alkylation (arylation)

被引：37

作者：

Halket, JM

Zaikin, VG

机构：

[1] Kings Coll London, Drug Control Ctr, London SE1 9NN, England

[2] Russian Acad Sci, AV Topchiev Petrochem Synth Inst, Moscow, Russia

来源：

EUROPEAN JOURNAL OF MASS SPECTROMETRY | 2004年 / 10卷 / 01期

关键词：

alcohols; alkylation; alkylating agents; alkyl halides; arylation; diazomethane; derivatives; derivatization; phenols; thiols; amines; amides; carboxylic acids; chemical warfare agents; phosphonic acids; phosphoric acids; sulfonic acids; pentafluorobenzyl derivatives; picolinyl esters; trimethylsilyldiazomethane; electron ionization; chemical ionization; gas chromatography/mass spectrometry; high-performance liquid chromatography/mass spectrometry;

D O I：

10.1255/ejms.619

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The review is devoted to alkylation (arylation) as a widely employed derivatization procedure for the protection of OH (carboxylic acids, phosphoric acids, sulfonic acids, alcohols, polyols, phenols, enols), SH (thiols) and NH (amines, amides) groups in order to increase volatility, to improve the chromatographic properties and, if possible, mass spectral properties of derivatives. Chemical aspects of derivatization and various alkylation (arylation) reagents and reaction procedures are described. Specific mass spectral (electron ionization, chemical ionization) features of derivatives helpful in identification, structure elucidation, profiling and quantitative determination of the above-mentioned polar compounds by coupled gas chromatography or high-performance liquid chromatography are discussed. Some common analytical applications of the procedures in organic chemistry, clinical chemistry, environmental chemistry etc. are briefly summarized.

引用

页码：1 / 19

页数：19

共 121 条

[81] Rapid detection of taxonomically important fatty acid methyl ester and steroid biomarkers using in situ thermal hydrolysis/methylation mass spectrometry (THM-MS): implications for bioaerosol detection [J].