Evaluation of Thermal and Nonthermal Effects of UHF RFID Exposure on Biological Drugs

被引：18

作者：

Calcagnini, Giovanni ^{[1
]}

Censi, Federica ^{[1
]}

Maffia, Michele ^{[2
,3
]}

Mainetti, Luca ^{[4
]}

Mattei, Eugenio ^{[1
]}

Patrono, Luigi ^{[4
]}

Urso, Emanuela ^{[2
]}

机构：

[1] Italian Natl Inst Hlth, Dept Technol & Hlth, I-00161 Rome, Italy

[2] Salento Univ, Dept Biol & Environm Sci & Technol, I-73100 Lecce, Italy

[3] Vito Fazzi Hosp, I-73100 Lecce, Italy

[4] Salento Univ, Dept Innovat Engn, I-73100 Lecce, Italy

来源：

IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE | 2012年 / 16卷 / 06期

关键词：

Biological effects of radiation; pharmaceuticals; product safety; radiofrequency identification;

D O I：

10.1109/TITB.2012.2204895

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

The radio frequency identification (RFID) technology promises to improve several processes in the healthcare scenario, especially those related to the traceability of people and things. Unfortunately, there are still some barriers limiting the large-scale deployment of these innovative technologies in the healthcare field. Among these, the evaluation of potential thermal and nonthermal effects due to the exposure of biopharmaceutical products to electromagnetic fields is very challenging, but still slightly investigated. This paper aims to setup a controlled RF exposure environment, in order to reproduce a worst case exposure of pharmaceutical products to the electromagnetic fields generated by the UHF RFID devices placed along the supply chain. Radiated powers several times higher than recommended by current normative limits were applied (10 and 20W). The electric field strength at the exposed sample location, used in tests, was as high as 100 V/m. Nonthermal effects were evaluated by chromatography techniques and in vitro assays. The results obtained for a particular case study, the ActrapidTM human insulin preparation, showed temperature increases lower than 0.5 degrees C and no significant changes in the structure and performance of the considered drug.

引用

页码：1051 / 1057

页数：7

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