Organocatalytic asymmetric conjugate addition of thioacetic acid to β-nitrostyrenes

被引：72

作者：

Li, H ^{[1
]}

Wang, H ^{[1
]}

Zu, LS ^{[1
]}

Wang, W ^{[1
]}

机构：

[1] Univ New Mexico, Dept Chem, Albuquerque, NM 87131 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 15期

关键词：

amine thiourea; asymmetric organocatalysis; Michael addition reaction; nitroolefins; thioacetic acid;

D O I：

10.1016/j.tetlet.2006.02.036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for organocatalytic, enantioselective Michael addition reactions of thioacetic acid with a range of trans-beta-nitrostyrenes has been developed. The processes, promoted by the chiral amine thiourea organocatalyst, take place in high yields with up to 70% ee. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2585 / 2589

页数：5

共 70 条

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