2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease

被引：14

作者：

Ertl, P ^{[1
]}

Cooper, D ^{[1
]}

Allen, G ^{[1
]}

Slater, MJ ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(99)00489-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A random screening approach has identified 2-chloro-3-substituted-1,4-naphthoquinones as potent inactivators of HCMV protease. Enzyme inactivation is due to modification of Cys202. Two of the most potent compounds maintain activity against HCMV in a plaque reduction assay. (C) 1999 Elsevier Science Ltd. Ail rights reserved.

引用

页码：2863 / 2866

页数：4

共 21 条

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