2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease

被引：14

作者：

Ertl, P ^{[1
]}

Cooper, D ^{[1
]}

Allen, G ^{[1
]}

Slater, MJ ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(99)00489-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A random screening approach has identified 2-chloro-3-substituted-1,4-naphthoquinones as potent inactivators of HCMV protease. Enzyme inactivation is due to modification of Cys202. Two of the most potent compounds maintain activity against HCMV in a plaque reduction assay. (C) 1999 Elsevier Science Ltd. Ail rights reserved.

引用

页码：2863 / 2866

页数：4

共 21 条

[11] HUDSON AT, 1986, EUR J MED CHEM, V21, P271
[12] SERIOUS CYTOMEGALO-VIRUS DISEASE IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)
JACOBSON, MA
MILLS, J
[J]. ANNALS OF INTERNAL MEDICINE, 1988, 108 (04) : 585 - 594
[13] Characterization of a soluble stable human cytomegalovirus protease and inhibition by M-site peptide mimics
LaFemina, RL
Bakshi, K
Long, WJ
Pramanik, B
Veloski, CA
Wolanski, BS
Marcy, AI
Hazuda, DJ
[J]. JOURNAL OF VIROLOGY, 1996, 70 (07) : 4819 - 4824
[14] MYERS JD, 1986, J INFECT DIS, V153, P478
[15] Peptidomimetic inhibitors of the human cytomegalovirus protease
Ogilvie, W
Bailey, M
Poupart, MA
Abraham, A
Bhavsar, A
Bonneau, P
Bordeleau, J
Bousquet, Y
Chabot, C
Duceppe, JS
Fazal, G
Goulet, S
GrandMaitre, C
Guse, I
Halmos, T
Lavallee, P
Leach, M
Malenfant, E
OMeara, J
Plante, R
Plouffe, C
Poirier, M
Soucy, F
Yoakim, C
Deziel, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (25) : 4113 - 4135
[16] QUI X, 1996, NATURE, V383, P275
[17] Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides
Rahim, SG
Trivedi, N
BogunovicBatchelor, MV
Hardy, GW
Mills, G
Selway, JWT
Snowden, W
Littler, E
Coe, PL
Basnak, I
Whale, RF
Walker, RT
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (03) : 789 - 795
[18] Three dimensional structure of human cytomegalovirus protease
Shieh, HS
Kurumbail, RG
Stevens, AM
Stegeman, RA
Sturman, EJ
Pak, JY
Wittwer, AJ
Palmier, MO
Wiegand, RC
Holwerda, BC
Stallings, WC
[J]. NATURE, 1996, 383 (6597) : 279 - 282
[19] A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease
Tong, L
Qian, CG
Massariol, MJ
Bonneau, PR
Cordingley, MG
Lagace, L
[J]. NATURE, 1996, 383 (6597) : 272 - 275
[20] β-lactam derivatives as inhibitors of human cytomegalovirus protease
Yoakim, C
Ogilvie, WW
Cameron, DR
Chabot, C
Guse, I
Haché, B
Naud, J
O'Meara, JA
Plante, R
Déziel, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (15) : 2882 - 2891

← 1 2 3 →