T Helper 17 Cells in Airway Diseases From Laboratory Bench to Bedside

被引：88

作者：

Halwani, Rabih ^{[1
]}

Al-Muhsen, Saleh ^{[1
]}

Hamid, Qutayba ^{[1
,2
]}

机构：

[1] King Saud Univ, Coll Med, Prince Naif Ctr Immunol Res, Riyadh 11461, Saudi Arabia

[2] McGill Univ, Meakins Christie Labs, Fac Med, Montreal, PQ H2X 2P2, Canada

来源：

CHEST | 2013年 / 143卷 / 02期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; ACTIVE CROHNS-DISEASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; BRONCHIAL EPITHELIAL-CELLS; REGULATES IL-17 EXPRESSION; SMOOTH-MUSCLE-CELLS; ROR-GAMMA-T; ALLERGIC-ASTHMA; T(H)17 CELLS; TGF-BETA;

D O I：

10.1378/chest.12-0598

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

T helper 17 (Th17) cytokines are now widely believed to be critical for the regulation of various chronic immune diseases. Investigations have revealed a significant role for IL-17 cytokines in regulating inflammation and modulating lung and airway structural cells in asthma and COPD. In this review, our current understanding of the role of Th17-associated cytokines in airway diseases is summarized. Therapeutic approaches targeting IL-17 during asthma and COPD are also discussed. CHEST 2013; 143(2):494-501

引用

收藏

页码：494 / 501

页数：8

相关论文

共 96 条

[1]

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2]

TH17-associated cytokines (IL-17A and IL-17F) in severe asthma [J].

Al-Ramli, Wisam ;

Prefontaine, David ;

Chouiali, Fazila ;

Martin, James G. ;

Olivenstein, Ron ;

Lamiere, Catherine ;

Hamid, Qutayba .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (05) :1185-1187

[3]

TH17 Cells in Asthma and COPD [J].

Alcorn, John F. ;

Crowe, Christopher R. ;

Kolls, Jay K. .

ANNUAL REVIEW OF PHYSIOLOGY, 2010, 72 :495-516

[4]

Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease [J].

Anderson, Gary P. .

LANCET, 2008, 372 (9643) :1107-1119

[5]

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt [J].

Ayyoub, Maha ;

Deknuydt, Florence ;

Raimbaud, Isabelle ;

Dousset, Christelle ;

Leveque, Lucie ;

Bioley, Gilles ;

Valmori, Danila .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (21) :8635-8640

[6]

Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine [J].

Barczyk, A ;

Pierzchala, W ;

Sozañska, E .

RESPIRATORY MEDICINE, 2003, 97 (06) :726-733

[7]

IL-17-producing human peripheral regulatory T cells retain suppressive function [J].

Beriou, Gaelle ;

Costantino, Cristina M. ;

Ashley, Charles W. ;

Yang, Li ;

Kuchroo, Vijay K. ;

Baecher-Allan, Clare ;

Hafler, David A. .

BLOOD, 2009, 113 (18) :4240-4249

[8]

Induction and effector functions of TH17 cells [J].

Bettelli, Estelle ;

Korn, Thomas ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE, 2008, 453 (7198) :1051-1057

[9]

Billich A, 2007, IDRUGS, V10, P53

[10]

IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? [J].

Bullens, Dominique M. A. ;

Truyen, Els ;

Coteur, Liesbeth ;

Dilissen, Ellen ;

Hellings, Peter W. ;

Dupont, Lieven J. ;

Ceuppens, Jan L. .

RESPIRATORY RESEARCH, 2006, 7 (1)

← 1 2 3 4 5 6 7 8 9 10 →