Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt

被引：252

作者：

Ayyoub, Maha ^{[1
]}

Deknuydt, Florence ^{[1
]}

Raimbaud, Isabelle ^{[1
]}

Dousset, Christelle ^{[1
]}

Leveque, Lucie ^{[1
]}

Bioley, Gilles ^{[1
]}

Valmori, Danila ^{[1
,2
]}

机构：

[1] Ctr Rene Gauducheau, U892, INSERM, F-44800 St Herblain, France

[2] Univ Nantes, Fac Med, F-44093 Nantes, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2009年 / 106卷 / 21期

关键词：

GROWTH-FACTOR-BETA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PROINFLAMMATORY IL-17(+); CELL-DIFFERENTIATION; CUTTING EDGE; HELPER-CELLS; TH17; CELLS; TGF-BETA; RECEPTOR; INDUCTION;

D O I：

10.1073/pnas.0900621106

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies have suggested a close relationship between CD4(+)FOXP3(+) regulatory T cells (Tregs) and proinflammatory IL-17-producing T helper cells (T(H)17) expressing the lineage-specific transcription factor ROR gamma t. We report here the unexpected finding that human memory Tregs secrete IL-17 ex vivo and constitutively express ROR gamma t. IL-17-secreting Tregs share some phenotypic and functional features with conventional T(H)17 cells, expressing high levels of CCR4 and CCR6 and low levels of CXCR3. However, unlike conventional T(H)17 cells, they express low levels of CD161 and mostly fail to cosecrete IL-22 and TNF-alpha ex vivo. Ex vivo secretion of IL-17 and constitutive expression of ROR gamma t by human memory Tregs suggest that, in addition to their well-known suppressive functions, these cells likely play additional, as yet undescribed, proinflammatory functions.

引用

页码：8635 / 8640

页数：6

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