New cyclic depsipeptides from the green alga Bryopsis species;: application of a carboxypeptidase hydrolysis reaction to the structure determination

被引：23

作者：

Dmitrenok, A

Iwashita, T

Nakajima, T

Sakamoto, B

Namikoshi, M

Nagai, H

机构：

[1] Tokyo Univ Marine Sci & Technol, Dept Ocean Sci, Minato Ku, Tokyo 1088477, Japan

[2] Suntory Inst Bioorgan Res, Osaka 6188503, Japan

[3] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA

来源：

TETRAHEDRON | 2006年 / 62卷 / 06期

关键词：

marine natural product; green alga; depsipeptide; carboxypeptidase;

D O I：

10.1016/j.tet.2005.10.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New cyclic depsipeptides, kahalalides P (1) and Q (2), were isolated from the Hawaiian green alga Bryopsis sp. The sequential positions of the DL anti-podal amino acids were determined by a carboxypeptidase hydrolysis reaction. This enzymatic method will be applicable to the structure determination of other non-ribosomal peptides. The absolute chemistry of 3-hydroxy-9-methyldecanoic acid in kahalalides P and Q were determined by the recently introduced convenient Mosher ester procedure. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：1301 / 1308

页数：8

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