A new depsipeptide from the sacoglossan mollusk Elysia ornata and the green alga Bryopsis species

被引：58

作者：

Horgen, FD

delos Santos, DB

Goetz, G

Sakamoto, B

Kan, Y

Nagai, H

Scheuer, PJ

机构：

[1] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA

[2] Suntory Inst Bioorgan Res, Mishima, Shizuoka 6188503, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 01期

关键词：

D O I：

10.1021/np990402o

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new cyclic depsipeptide, kahalalide O (1), was isolated from the sacoglossan Elysia ornata and its algal diet Bryopsis sp. The structure was elucidated primarily by NMR and MS spectral methods, and the stereochemistry of the amino acid residues was determined by chiral HPLC and Marfey analyses. Unlike the related metabolite kahalalide F, which is in development as a potential anticancer agent, kahalalide O (1) was inactive in arresting the growth of P-388, A549, HT29, and MEL28 cancer cell lines in vitro.

引用

页码：152 / 154

页数：3

共 9 条

[1]

*AM SOC PHARM, 1997, 39 ANN M AM SOC PHAR

[2] Two acyclic kahalalides from the sacoglossan mollusk Elysia rufescens [J].