Convenient and efficient synthesis of pyrazole-based DHODase inhibitors from 3-aryl-4-cyanosydnone

被引：19

作者：

Chang, EM

Chen, TH

Wong, FF

Chang, EC

Yeh, MY

机构：

[1] Natl Cheng Kung Univ, Sustainable Environm Res Ctr, Tainan 709, Taiwan

[2] Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan

[3] Nan Jeon Inst Technol, Yanshuei 737, Tainan County, Taiwan

来源：

SYNLETT | 2006年 / 06期

关键词：

sydnones; 13-dipolar cycloaddition; propargylic ester; pyrazole; DHODase inhibitors;

D O I：

10.1055/s-2006-939041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrazole-based DHODase inhibitors have been efficient and conveniently synthesized in 51-60% yield from 3-(p-aryl)-4cyanosydnone via regioselective 1,3-diploar cycloaddition followed by an amidation and a Ritter reaction.

引用

页码：901 / 904

页数：4

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