Asymmetric Synthesis of Medium-Sized Rings by Intramolecular Au(I)-Catalyzed Cyclopropanation

被引：207

作者：

Watson, Iain D. G. ^{[1
]}

Ritter, Stefanie ^{[1
]}

Toste, F. Dean ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 06期

关键词：

ENE-TYPE CYCLIZATION; STEREOSELECTIVE OLEFIN CYCLOPROPANATION; CATALYZED CYCLOISOMERIZATION; ENANTIOSELECTIVE SYNTHESIS; MACROCYCLE FORMATION; PROPARGYL ACETATES; GOLD CATALYSIS; PLATINUM; ALKYNES; ENYNES;

D O I：

10.1021/ja8085005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient method for the asymmetric gold (I)-catatyzed preparation of medium sized rings has been developed. The method provides 7- to 9-membered rings in excellent yield. High enantioselectivities can be achieved for 7- and 8-membered ring products employing chiral gold(I) complexes. The results provide insight into the mechanism, showing the fluxional nature of gold (I)-stabilized vinyl carbenoid intermediates.

引用

页码：2056 / +

页数：3

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