An approach to skeletal diversity using functional group pairing of multifunctional scaffolds

被引:109
作者
Comer, Eamon
Rohan, Erin
Deng, Li
Porco, John A., Jr.
机构
[1] Boston Univ, Dept Chem, Boston, MA 02215 USA
[2] Boston Univ, Ctr Chem Methodol & Lib Dev, Boston, MA 02215 USA
[3] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA
关键词
D O I
10.1021/ol070606t
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Diversification of enantioenriched Michael adducts through functional group pairing to gain access to a range of five- to ten-membered complex fused and bridged ring systems is described.
引用
收藏
页码:2123 / 2126
页数:4
相关论文
共 28 条
[1]   Exploring new chemical space by stereocontrolled diversity-oriented synthesis [J].
Arya, P ;
Joseph, R ;
Gan, ZH ;
Rakic, B .
CHEMISTRY & BIOLOGY, 2005, 12 (02) :163-180
[2]  
BAESL Y, 1997, SYNTHESIS-STUTTGART, P309
[3]  
Bentz D, 2000, SYNTHESIS-STUTTGART, P1766
[4]   When the Pauson-Khand and Pauson-Khand type reactions go awry:: a plethora of unexpected results [J].
Boñaga, LVR ;
Krafft, ME .
TETRAHEDRON, 2004, 60 (44) :9795-9833
[5]   Recent advances in the Pauson-Khand reaction and related [2+2+1] cycloadditions [J].
Brummond, KM ;
Kent, JL .
TETRAHEDRON, 2000, 56 (21) :3263-3283
[6]   A planning strategy for diversity-oriented synthesis [J].
Burke, MD ;
Schreiber, SL .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (01) :46-58
[7]   Convergent diversity-oriented synthesis of small-molecule hybrids [J].
Chen, C ;
Li, XD ;
Neumann, CS ;
Lo, MMC ;
Schreiber, SL .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (15) :2249-2252
[8]   An efficient method for removal of ruthenium byproducts from olefin metathesis reactions [J].
Cho, JH ;
Kim, BM .
ORGANIC LETTERS, 2003, 5 (04) :531-533
[9]  
Couladouros EA, 2002, ANGEW CHEM INT EDIT, V41, P3677, DOI 10.1002/1521-3773(20021004)41:19<3677::AID-ANIE3677>3.0.CO
[10]  
2-Y