Non-thiazolidinedione antihyperglycaemic agents.: Part 4:: Synthesis of ( plus /-)-, (R)-(+)- and (S)-(-)-enantiomers of 2-oxy-3-arylpropanoic acids

被引：24

作者：

Haigh, D

Birrell, HC

Cantello, BCC

Hindley, RM

Ramaswamy, A

Rami, HK

Stevens, NC

机构：

[1] SmithKline Beecham Pharmaceut, Dept Med Chem, Harlow CM19 5AW, Essex, England

[2] SmithKline Beecham Pharmaceut, Dept Analyt Sci, Harlow CM19 5AW, Essex, England

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 07期

关键词：

D O I：

10.1016/S0957-4166(99)00104-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of a new series of potent 2-oxy-3-arylpropanoic acid antihyperglycaemic agents in both racemic and non-racemic form is described. Resolution of racemic acids 1 is accomplished via amide formation with either (S)-2-phenylglycinol or (S)-4-benzyloxazolidin-2-one as complementary resolving agents. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1335 / 1351

页数：17

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