Non thiazolidinedione antihyperglycaemic agents .1. alpha-heteroatom substituted beta-phenylpropanoic acids

被引：55

作者：

Buckle, DR

Cantello, BCC

Cawthorne, MA

Coyle, PJ

Dean, DK

Faller, A

Haigh, D

Hindley, RM

Jefcott, LJ

Lister, CA

Pinto, IL

Rami, HK

Smith, DG

Smith, SA

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, DEPT MED CHEM, EPSOM KT18 5XQ, SURREY, ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT, DEPT VASC BIOL, EPSOM KT18 5XQ, SURREY, ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 17期

关键词：

D O I：

10.1016/0960-894X(96)00383-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of alpha-heteroatom functionalised beta-phenylpropanoic acids. alpha-Oxy-carboxylic acids show potent antidiabetic activity and one compound, the alpha-ethoxyacid 15 (SE 213068), is one of the mast potent antihyperglycaemic agents yet reported. Copyright (C) 1996 Elsevier Science Ltd

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页码：2121 / 2126

页数：6

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