Colon cancer prevention with NO-releasing NSAIDs

被引：17

作者：

Kaza, CS

Kashfi, K

Rigas, B

机构：

[1] Amer Hlth Fdn, Valhalla, NY 10595 USA

[2] New York Med Coll, Sarah C Upham Div Gastroenterol, Valhalla, NY 10595 USA

[3] CUNY, Sch Med, Dept Physiol & Pharmacol, New York, NY 10031 USA

[4] Rockefeller Univ, New York, NY 10021 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2002年 / 67卷 / 02期

关键词：

colon cancer; nitric oxide; non-steroidal anti-inflammatory drugs; chemoprevention;

D O I：

10.1016/S0090-6980(02)00003-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A seminal advance in the prevention of colon cancer has been the observation that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the incidence of and mortality from colon cancer by about half. Among current efforts to overcome the side effects of NSAIDs, an important limitation for their application as chemopreventive agents, is the synthesis of nitric oxide-releasing NSAIDs. These novel compounds may display greater safety and greater efficacy compared to their parent traditional NSAIDs and thus hold significant promise as chemopreventive agents against human colon cancer. In this review we discuss salient features of their pharmacology, in vitro and animal data pertaining to colon cancer, their mechanisms of action, and assess their potential in the chemoprevention of colon cancer. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：107 / 120

页数：14

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