A methodology for solving physiologically based pharmacokinetic models without the use of simulation softwares

被引：34

作者：

Haddad, S ^{[1
]}

Pelekis, M ^{[1
]}

Krishnan, K ^{[1
]}

机构：

[1] UNIV MONTREAL,FAC MED,DEPT MED TRAVAIL & HYG MILIEU,MONTREAL,PQ H3T 1A8,CANADA

来源：

TOXICOLOGY LETTERS | 1996年 / 85卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

PBPK modeling; spreadsheet programs; styrene; physiological pharmacokinetics;

D O I：

10.1016/0378-4274(96)03648-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The objective of the present study was to develop and validate a methodology for solving physiologically based pharmacokinetic (PBPK) models without the use of simulation software. The approach involves keying the parameter values and model equations into Microsoft Excel(R) spreadsheets, and conducting simulations by solving the model equations according to Euler's method of numerical integration. This approach was applied to simulate the pharmacokinetics of styrene in rats exposed to 80 and 600 ppm for 6 h. The simulation results were plotted along with experimental data using the regular graphic features available in Excel(R), and validated by comparing them with simulation results obtained using a commercially available software (Advanced Continuous Simulation Language, ACSL(R)). The simulations obtained with ACSL(R) and Excel(R), in general, differed by < 1%. The methodology developed in the present study should help informed individuals understand and solve PBPK models, without having to use 'black-box' kind of computer programs and simulation softwares.

引用

页码：113 / 126

页数：14