AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

被引：253

作者：

Zaha, Vlad G.

Young, Lawrence H. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Sect Cardiovasc Med, Dept Internal Med, New Haven, CT 06520 USA

来源：

CIRCULATION RESEARCH | 2012年 / 111卷 / 06期

基金：

美国国家卫生研究院;

关键词：

cardiac metabolism; cardioprotection; heart failure; myocardial ischemia; protein kinases; FATTY-ACID OXIDATION; PARKINSON-WHITE-SYNDROME; ACETYL-COA CARBOXYLASE; MIGRATION INHIBITORY FACTOR; GLYCOGEN-STORAGE CARDIOMYOPATHY; ISCHEMIA-REPERFUSION INJURY; LOW-FLOW ISCHEMIA; SKELETAL-MUSCLE; CARDIAC-HYPERTROPHY; PRESSURE-OVERLOAD;

D O I：

10.1161/CIRCRESAHA.111.255505

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AMP-activated protein kinase (AMPK) is a stress-activated kinase that functions as a cellular fuel gauge and master metabolic regulator. Recent investigation has elucidated novel molecular mechanisms of AMPK regulation and important biological actions of the AMPK pathway that are highly relevant to cardiovascular disease. Activation of the intrinsic AMPK pathway plays an important role in the myocardial response to ischemia, pressure overload, and heart failure. Pharmacological activation of AMPK shows promise as a therapeutic strategy in the treatment of heart disease. The purpose of this review is to assess how recent discoveries have extended and in some cases challenged existing paradigms, providing new insights into the regulation of AMPK, its diverse biological actions, and therapeutic potential in the heart. (Circ Res. 2012;111:800-814.)

引用

页码：800 / 814

页数：15

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