Metabolic syndrome and the risk for recurrent pre-eclampsia: a retrospective cohort study

被引：25

作者：

Stekkinger, E. ^{[1
]}

Scholten, R. R. ^{[2
]}

van der Vlugt, M. J. ^{[3
]}

van Dijk, A. P. J. ^{[3
]}

Janssen, M. C. H. ^{[4
]}

Spaanderman, M. E. A. ^{[2
,5
]}

机构：

[1] Deventer Hosp, Dept Obstet & Gynaecol, NL-7400 GC Deventer, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Obstet & Gynaecol, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[5] Maastricht Univ, Med Ctr, Res Sch GROW, Maastricht, Netherlands

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2013年 / 120卷 / 08期

关键词：

Metabolic syndrome; recurrence; pre-eclampsia; TIME PHYSICAL-ACTIVITY; LIFE-STYLE INTERVENTION; LOW-PLASMA-VOLUME; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; DIABETES-MELLITUS; PREGNANCY; PREVENTION; IMPACT;

D O I：

10.1111/1471-0528.12189

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective To compare the prevalence of recurrent pre-eclampsia between women who have and do not have metabolic syndrome when non-pregnant. Design Retrospective cohort study. Setting Three tertiary referral hospitals in the Netherlands. Population Formerly pre-eclamptic women. Methods The presence or absence of metabolic syndrome was assessed in 480 women at least 6months after their first pre-eclamptic pregnancy using World Health Organization criteria. We compared the prevalence of recurrent pre-eclampsia in the subsequent pregnancy, calculating odds ratios (OR), adjusted for confounders. Main outcome measure Recurrence of pre-eclampsia in the subsequent pregnancy. Results Subsequent pregnancy outcome data were available for 197 women. Forty women had metabolic syndrome after previous pregnancy (20%). The prevalence of recurrent pre-eclampsia was 18/40 (45%) in women with metabolic syndrome versus 27/157 (17%) in women without metabolic syndrome; OR 3.94 (95% confidence interval [CI] 1.86-8.33, adjusted OR 3.77 (95% CI 1.61-8.81). The risk of recurrent pre-eclampsia increased with each extra component of the metabolic syndrome from 11.8% for absent components up to 43.9% for three or more (P for trend<0.001). Conclusions Interpregnancy metabolic syndrome predisposes to recurrent pre-eclampsia.

引用

页码：979 / 986

页数：8