Mammalian homologues of the Drosophila eye specification genes

被引：84

作者：

Hanson, IM ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Dept Med Sci,Med Genet Sect, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2001年 / 12卷 / 06期

基金：

英国医学研究理事会;

关键词：

DACH; EYA; eyeless; PAX6; SIX;

D O I：

10.1006/scdb.2001.0271

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Drosophila compound eye is specified by the simultaneous and interdependent activity of transcriptional regulatory genes from four families: PAX6 (eyeless, train of eyeless, eyegone), EYA (eyes absent), SIX (sine oculis, Optix) and DACH (dachshund). Mammals have homologues of all these genes, and many of thorn are expressed in the embryonic or adult eye, but the functional relationships between them are currently much less clear than in Drosophila. Nevertheless, mutations in the mammalian genes highlight their requirement both within and outside the eye in embryos and adults, and emphasize that they can be deployed in many different contexts.

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收藏

页码：475 / 484

页数：10

相关论文

共 57 条

[1] A human homologue of the Drosophila eyes absent gene underlies Branchio-Oto-Renal (BOR) syndrome and identifies a novel gene family [J].

Abdelhak, S ;

Kalatzis, V ;

Heilig, R ;

Compain, S ;

Samson, D ;

Vincent, C ;

Weil, D ;

Cruaud, C ;

Sahly, I ;

Leibovici, M ;

BitnerGlindzicz, M ;

Francis, M ;

Lacombe, D ;

Vigneron, J ;

Charachon, R ;

Boven, K ;

Bedbeder, P ;

VanRegemorter, N ;

Weissenbach, J ;

Petit, C .

NATURE GENETICS, 1997, 15 (02) :157-164

[2] Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye [J].

Ashery-Padan, R ;

Marquardt, T ;

Zhou, XL ;

Gruss, P .

GENES & DEVELOPMENT, 2000, 14 (21) :2701-2711

[3] Missense mutation in the alternative splice region of the PAX6 gene in eye anomalies [J].

Azuma, N ;

Yamaguchi, Y ;

Handa, H ;

Hayakawa, M ;

Kanai, A ;

Yamada, M .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (03) :656-663

[4] Mutations of a human homologue of the Drosophila eyes absent gene (EYA1) detected in patients with congenital cataracts and ocular anterior segment anomalies [J].

Azuma, N ;

Hirakiyama, A ;

Inoue, T ;

Asaka, A ;

Yamada, M .

HUMAN MOLECULAR GENETICS, 2000, 9 (03) :363-366

[5] EYA4, a novel vertebrate gene related to Drosophila eyes absent [J].

Borsani, G ;

DeGrandi, A ;

Ballabio, A ;

Bulfone, A ;

Bernard, L ;

Banfi, S ;

Gattuso, C ;

Mariani, M ;

Dixon, M ;

Donnai, D ;

Metcalfe, K ;

Winter, R ;

Robertson, M ;

Axton, R ;

Brown, A ;

van Heyningen, V ;

Hanson, I .

HUMAN MOLECULAR GENETICS, 1999, 8 (01) :11-23

[6]

Bui QT, 2000, GENETICS, V155, P709

[7] Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila [J].

Chen, R ;

Amoui, M ;

Zhang, ZH ;

Mardon, G .

CELL, 1997, 91 (07) :893-903

[8]

Chow RL, 1999, DEVELOPMENT, V126, P4213

[9] Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents [J].

Cohen, SB ;

Zheng, GX ;

Heyman, HC ;

Stavnezer, E .

NUCLEIC ACIDS RESEARCH, 1999, 27 (04) :1006-1014

[10]

Collinson JM, 2000, DEVELOPMENT, V127, P945

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