Mammalian homologues of the Drosophila eye specification genes

被引：84

作者：

Hanson, IM ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Dept Med Sci,Med Genet Sect, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2001年 / 12卷 / 06期

基金：

英国医学研究理事会;

关键词：

DACH; EYA; eyeless; PAX6; SIX;

D O I：

10.1006/scdb.2001.0271

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Drosophila compound eye is specified by the simultaneous and interdependent activity of transcriptional regulatory genes from four families: PAX6 (eyeless, train of eyeless, eyegone), EYA (eyes absent), SIX (sine oculis, Optix) and DACH (dachshund). Mammals have homologues of all these genes, and many of thorn are expressed in the embryonic or adult eye, but the functional relationships between them are currently much less clear than in Drosophila. Nevertheless, mutations in the mammalian genes highlight their requirement both within and outside the eye in embryos and adults, and emphasize that they can be deployed in many different contexts.

引用

收藏

页码：475 / 484

页数：10

相关论文

共 57 条

[11] Lens development and crystallin gene expression: Many roles for Pax-6 [J].

Cvekl, A ;

Piatigorsky, J .

BIOESSAYS, 1996, 18 (08) :621-630

[12] twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development [J].

Czerny, T ;

Halder, G ;

Kloter, U ;

Souabni, A ;

Gehring, WJ ;

Busslinger, M .

MOLECULAR CELL, 1999, 3 (03) :297-307

[13] Characterization of mouse Dach2, a homologue of Drosophila dachshund [J].

Davis, RJ ;

Shen, WP ;

Sandler, YI ;

Heanue, TA ;

Mardon, G .

MECHANISMS OF DEVELOPMENT, 2001, 102 (1-2) :169-179

[14] Dach1 mutant mice bear no gross abnormalities in eye, limb, and brain development and exhibit postnatal lethality [J].

Davis, RJ ;

Shen, WP ;

Sandler, YI ;

Amoui, M ;

Purcell, P ;

Maas, R ;

Ou, CN ;

Vogel, H ;

Beaudet, AL ;

Mardon, G .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (05) :1484-1490

[15] The α subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins [J].

Fan, XM ;

Brass, LF ;

Poncz, M ;

Spitz, F ;

Maire, P ;

Manning, DR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (41) :32129-32134

[16]

Fuhrmann S, 2000, Results Probl Cell Differ, V31, P69

[17] Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies [J].

Gallardo, ME ;

Lopez-Rios, J ;

Fernaud-Espinosa, I ;

Granadino, B ;

Sanz, R ;

Ramos, C ;

Ayuso, C ;

Seller, MJ ;

Brunner, HG ;

Bovolenta, P ;

de Córdoba, SR .

GENOMICS, 1999, 61 (01) :82-91

[18] Pax 6 - mastering eye morphogenesis and eye evolution [J].

Gehring, WJ ;

Ikeo, K .

TRENDS IN GENETICS, 1999, 15 (09) :371-377

[19] Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb [J].

Hammond, KL ;

Hanson, IM ;

Brown, AG ;

Lettice, LA ;

Hill, RE .

MECHANISMS OF DEVELOPMENT, 1998, 74 (1-2) :121-131

[20] Missense mutations in the most ancient residues of the PAX6 paired domain underlie a spectrum of human congenital eye malformations [J].

Hanson, I ;

Churchill, A ;

Love, J ;

Axton, R ;

Moore, T ;

Clarke, M ;

Meire, F ;

van Heyningen, V .

HUMAN MOLECULAR GENETICS, 1999, 8 (02) :165-172

← 1 2 3 4 5 6 →