Dendritic cells: Immune regulators in health and disease

被引:329
作者
Lipscomb, MF [1 ]
Masten, BJ [1 ]
机构
[1] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA
关键词
D O I
10.1152/physrev.00023.2001
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as well as nearly all nonlymphoid tissues and organs. Although DCs are a moderately diverse set of cells, they all have potent antigen-presenting capacity for stimulating naive, memory, and effector T cells. DCs are members of the innate immune system in that they can respond to dangers in the host environment by immediately generating protective cytokines. Most important, immature DCs respond to danger signals in the microenvironment by maturing, i.e., differentiating, and acquiring the capacity to direct the development of primary immune responses appropriate to the type of danger perceived. The powerful adjuvant activity that DCs possess in stimulating specific CD4 and CD8 T cell responses has made them targets in vaccine development strategies for the prevention and treatment of infections, allograft reactions, allergic and autoimmune diseases, and cancer. This review addresses the origins and migration of DCs to their sites of activity, their basic biology as antigen-presenting cells, their roles in important human diseases and, finally, selected strategies being pursued to harness their potent antigen-stimulating activity.
引用
收藏
页码:97 / 130
页数:34
相关论文
共 416 条
[11]   Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse [J].
Anjuère, F ;
Martín, P ;
Ferrero, I ;
Fraga, ML ;
del Hoyo, GM ;
Wright, N ;
Ardavin, C .
BLOOD, 1999, 93 (02) :590-598
[12]  
Apostolopoulos V, 1999, CURR OPIN MOL THER, V1, P98
[13]   Thymic dendritic cells [J].
Ardavin, C .
IMMUNOLOGY TODAY, 1997, 18 (07) :350-361
[14]   CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms [J].
Askew, D ;
Chu, RS ;
Krieg, AM ;
Harding, CV .
JOURNAL OF IMMUNOLOGY, 2000, 165 (12) :6889-6895
[15]   THE ROLE OF INDIRECT RECOGNITION IN INITIATING REJECTION OF SKIN-GRAFTS FROM MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II-DEFICIENT MICE [J].
AUCHINCLOSS, H ;
LEE, R ;
SHEA, S ;
MARKOWITZ, JS ;
GRUSBY, MJ ;
GLIMCHER, LH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3373-3377
[16]  
AUSTYN JM, 1994, J IMMUNOL, V152, P2401
[17]   Antigen-presenting cells - Experimental and clinical studies of dendritic cells [J].
Austyn, JM .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (04) :S146-+
[18]   Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype [J].
Aversa, F ;
Tabilio, A ;
Velardi, A ;
Cunningham, I ;
Terenzi, A ;
Falzetti, F ;
Ruggeri, L ;
Barbabietola, G ;
Aristei, C ;
Latini, P ;
Reisner, Y ;
Martelli, MF .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (17) :1186-1193
[19]   Distinct roles for LFA-1 and CD28 during activation of naive T cells: Adhesion versus costimulation [J].
Bachmann, MF ;
McKallFaienza, K ;
Schmits, R ;
Bouchard, D ;
Beach, J ;
Speiser, DE ;
Mak, TW ;
Ohashi, PS .
IMMUNITY, 1997, 7 (04) :549-557
[20]   Chemokines and leukocyte traffic [J].
Baggiolini, M .
NATURE, 1998, 392 (6676) :565-568