The vacuolar (H+)-atpases -: Nature's most versatile proton pumps

被引:1001
作者
Nishi, T [1 ]
Forgac, M [1 ]
机构
[1] Tufts Univ, Sch Med, Dept Physiol, Boston, MA 02111 USA
关键词
D O I
10.1038/nrm729
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The pH of intracellular compartments in eukaryotic cells is a carefully controlled parameter that affects many cellular processes, including intracellular membrane transport, prohormone processing and transport of neurotransmitters, as well as the entry of many viruses into cells, The transporters responsible for controlling this crucial parameter in many intracellular compartments are the vacuolar (H+)-ATPases (V-ATPases). Recent advances in our understanding of the structure and regulation of the V-ATPases, together with the mapping of human genetic defects to genes that encode V-ATPase subunits, have led to tremendous excitement in this field.
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页码:94 / 103
页数:10
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