Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobactetium tuberculosis isolates

被引：70

作者：

Plinke, C ^{[1
]}

Rüsch-Gerdes, S ^{[1
]}

Niemann, S ^{[1
]}

机构：

[1] Forschungszentrum Borstel, Natl Reference Ctr Mycobacteria, D-23845 Borstel, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 05期

关键词：

D O I：

10.1128/AAC.50.5.1900-1902.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB] -resistant strains, 33 multidrugresistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 (embB306). Mutations were detected only in EMB-resistant strains (n = 69; 68%), thus confirming the significance of embB306 mutations for the prediction of resistance to EMB.

引用

页码：1900 / 1902

页数：3

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