Novel mutations within the embB gene in ethambutol-susceptible clinical isolates of Mycobacterium tuberculosis

被引:57
作者
Lee, ASG [1 ]
Othman, SNK
Ho, YM
Wong, SY
机构
[1] Natl Canc Ctr, Div Med Sci, Singapore 169610, Singapore
[2] Tan Tock Seng Hosp, Dept Infect Dis, Singapore, Singapore
关键词
D O I
10.1128/AAC.48.11.4447-4449.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Genetic analysis of the embB gene revealed mutations in 17 (68%) of 25 ethambutol (EMB) resistant isolates (M306I, M306V, M306L, Q497R) but also in 4 (20%) of 20 EMB-susceptible isolates of Mycobacterium tuberculosis, namely, an ATG --> ATM substitution resulting in M3061, G406N, and the novel alterations M423I and A659T.
引用
收藏
页码:4447 / 4449
页数:3
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