Contribution of kasA analysis to detection of isoniazid-resistant Mycobacterium tuberculosis in Singapore

被引：103

作者：

Lee, ASG

Lim, IHK

Tang, LLH

Telenti, A

Wong, SY

机构：

[1] Singapore Gen Hosp, Dept Clin Res, Minist Hlth, Singapore 169608, Singapore

[2] Tan Tock Seng Hosp, Communicable Dis Ctr, Singapore 308433, Singapore

[3] CHU Vaudois, Div Infect Dis, CH-1011 Lausanne, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 08期

关键词：

D O I：

10.1128/AAC.43.8.2087

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genotypic analysis of resistance to isoniazid (INH) in Mycobacterium tuberculosis is complex due to the various genes potentially involved. Mutations in ketoacyl acyl carrier protein synthase (encoded by kasA) were present in 16 of 160 (10%) INH-resistant isolates (R121K [n = 1], G269S [n = 3], G312S [n = 11], G387D [n = 1]). However, G312S was also present in 6 of 32 (19%) susceptible strains. kasA analysis contributed marginally to the performance of INH genotypic testing in Singapore. The significance of kasA polymorphisms in INH resistance should be carefully established.

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页码：2087 / 2089

页数：3

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