Anti-sense oligodeoxynucleoside phosphorothioates nonspecifically inhibit invasion of red blood cells by malaria parasites

被引：19

作者：

Ramasamy, R

Kanagaratnam, R

Misiura, K

Rebowski, G

Amerakoon, R

Stec, WJ

机构：

[1] UNIV JAFFNA,FAC MED,JAFFNA,SRI LANKA

[2] POLISH ACAD SCI,CTR MOLEC & MACROMOLEC STUDIES,PL-90363 LODZ,POLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 218卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.0164

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anti-sense and sense oligodeoxynucleoside phosphorothioates, based on analysis of the secondary structure of Plasmodium falciparumdihydrofolate reductase-thymidylate synthase mRNA, were synthesized. Their effects on P. falciparum growth in vitro were examined by microscopy and [H-3] hypoxanthine incorporation. Both anti-sense and sense oligodeoxynucleoside phosphorothioares inhibit invasion of red blood cells by merozoites and this is interpreted as being caused by their polyanionic nature. Specific anti-sense effects of the oligonucleoside phosphorothioates could not however be demonstrated. (C) 1996 Academic Press, Inc.

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页码：930 / 933

页数：4

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