An improved total synthesis of PET HSV-tk gene reporter probe 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG)

被引：12

作者：

Zheng, QH

Wang, JQ

Liu, X

Fei, XS

Mock, BH

Glick-Wilson, BE

Sullivan, ML

Raikwar, SP

Gardner, TA

Kao, CH

Hutchins, GD

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Urol, Indianapolis, IN 46202 USA

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 04期

基金：

美国国家卫生研究院;

关键词：

9-(4-[F-18]fluoro-3-hydroxymethylbutyl)guinine ([F-18]FHBG); penciclovir (PCV); synthesis; positron emission tomography (PET); herpes simplex virus thymidine kinase (HSV-tk); gene expression;

D O I：

10.1081/SCC-120027717

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved total synthesis of [F-18]FHBG starting from triethyl-1,1,2-ethanetricarboxylate and 2-amino-6-chloropurine is reported. [F-18]FHBG was prepared by nucleophilic Substitution of the appropriate precursor with [F-18]KF/Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 20-25% radiochemical yield.

引用

收藏

页码：689 / 704

页数：16

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