A case of voltage-gated potassium channel antibody-related limbic encephalitis

被引：21

作者：

Harrower, T

Foltynie, T

Kartsounis, L

De Silva, RN

Hodges, JR

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Neurosci, Cambridge CB2 2QQ, England

[2] Oldchurch Hosp, Romford, Essex, England

来源：

NATURE CLINICAL PRACTICE NEUROLOGY | 2006年 / 2卷 / 06期

基金：

英国医学研究理事会;

关键词：

hyponatremia; immunomodulatory therapy; limbic encephalitis; voltage-gated potassium channel antibodies;

D O I：

10.1038/ncpneuro0194

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background A 56-year-old man presented to hospital with a 6-month history of recurrent episodes of altered behavior and 'odd' episodes. He had become apathetic and uninterested in his family. He had no relevant past medical or family history. General and physical neurological examinations were unremarkable, as was bedside cognitive testing. Investigations Brain MRI scan, 24-h electroencephalogram, serum and cerebrospinal fluid testing for voltage-gated potassium channel antibodies, blood screening for tumors, CT scans of the chest, abdomen and pelvis, whole-body PET scan, neuropsychological examination, brain F-18-fluorodeoxyglucose-PET scan. Diagnosis Voltage-gated potassium channel antibody-related limbic encephalitis. Management Antiepileptic drugs, immunomodulatory therapy, oral steroids, plasma exchange.

引用

页码：339 / 343

页数：5

共 17 条

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PARTHASARATHI UD, IN PRESS BR J PSYCHI

[12] Voltage-gated potassium channel antibodies in limbic encephalitis [J].