State of the art and challenges of time-of-flight PET

被引：222

作者：

Conti, Maurizio ^{[1
]}

机构：

[1] Siemens Healthcare, Mol Imaging, Knoxville, TN 37932 USA

来源：

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS | 2009年 / 25卷 / 01期

关键词：

Positron emission tomography; Time of flight; TOF reconstruction; TOF PET; Scintillation detectors; TOF gain; Signal-to-noise ratio; POSITRON-EMISSION-TOMOGRAPHY; GAMMA-RAY SPECTROSCOPY; SCINTILLATION PROPERTIES; ENERGY-RESOLUTION; IMAGE-RECONSTRUCTION; TIMING RESOLUTION; TOF PET; 3-D PET; LSO; LUMINESCENCE;

D O I：

10.1016/j.ejmp.2008.10.001

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

After a brief review of the history of time-of-flight (TOF) positron emission tomography (PET) instrumentation from the 1980s to present, the principles of TOF PET are introduced, the concept of time resolution and its effect on TOF gain in signal-to-noise ratio (SNR) are discussed. The factors influencing the time resolution of a TOF PET scanner are presented, with focus on the intrinsic properties of scintillators of particular interest for TOF PET. Finally, some open issues, challenges and achievements of today's TOF PET reconstruction are reviewed: the structure of the data organization, the choice of analytical. or iterative method, the recent experimental assessment of TOF image quality, and the most promising applications of TOF PET. (C) 2008 Associazione Itatiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

引用

页码：1 / 11

页数：11

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