Ribonucleotide reductases: metal and free radical interplay

被引：25

作者：

Mulliez, E ^{[1
]}

Fontecave, M ^{[1
]}

机构：

[1] Univ Grenoble 1, EP 1087 CNRS, CEA Grenoble, CB,DBMS,Lab Chim & Biochim,Ctr Redox Biol, F-38054 Grenoble 9, France

来源：

COORDINATION CHEMISTRY REVIEWS | 1999年 / 185-6卷

关键词：

ribonucleotide reductases; radical activation; DNA;

D O I：

10.1016/S0010-8545(99)00044-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In the cell, the only de novo biosynthetic pathway to desoxyribonucleotides is by reduction of their ribonucleotide counterparts. This reaction is catalysed by the ribonucleotide reductases. Three classes of these metalloenzymes are known which all resort to the same synthetic strategy: radical activation of the substrate by means of a protein free radical followed by a three-electron reduction step.. The nature of the essential protein free radical and its generation differ widely from one class to an other. In this paper, the characteristics of the different metal and radical interplay of each clasp are reviewed. (C) 1999 Elsevier Science S.A. All rights reserved.

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收藏

页码：775 / 793

页数：19

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