Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals

被引:168
作者
Verpoorte, R [1 ]
van der Heijden, R
ten Hoopen, HJG
Memelink, J
机构
[1] Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Pharmacognosy, Leiden, Netherlands
[2] Delft Univ Technol, Dept Biochem Engn, NL-2628 BC Delft, Netherlands
[3] Leiden Univ, Inst Mol Plant Sci, Leiden, Netherlands
关键词
genetic modification; metabolic engineering; phytochemicals; plant cell biotechnology; plant cell culture; plant secondary metabolism;
D O I
10.1023/A:1005502632053
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The technology of large-scale plant cell culture is feasible for the industrial production of plant-derived fine chemicals. Due to low or no productivity of the desired compounds the economy is only in a few cases favorable. Various approaches are studied to increase yields, these encompass screening and selection of high producing cell lines, media optimization, elicitation, culturing of differentiated cells (organ cultures), immobilization. In recent years metabolic engineering has opened a new promising perspectives for improved production in a plant or plant cell culture.
引用
收藏
页码:467 / 479
页数:13
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