Application of magnetic resonance to animal models of cerebral ischemia

被引：112

作者：

Hoehn, M ^{[1
]}

Nicolay, K ^{[1
]}

Franke, C ^{[1
]}

van der Sanden, B ^{[1
]}

机构：

[1] Max Planck Inst Neurol Res, D-50931 Cologne, Germany

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2001年 / 14卷 / 05期

关键词：

MRI; MRS; fMRI; cerebral ischemia; thrombolysis; transgenic mice;

D O I：

10.1002/jmri.1213

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The present review has been compiled to highlight the role of magnetic resonance imaging (MRI) and MR spectroscopy (MRS) for the investigation of cerebral ischemia in the animal experimental field of basic research. We have focused on stroke investigations analyzing the pathomechanisms of the disease evolution and on new advances in both nuclear MR (NMR) methodology or genetic engineering of transgenic animals for the study of complex molecular relationships and causes of the disease. Furthermore, we have tried to include metabolic and genetic aspects, as well as the application of functional imaging, for the investigation of the disturbance or restitution of functional brain activation under pathological conditions as relates to controlled animal experiments. (C) 2001 Wiley-Liss, Inc.

引用

页码：491 / 509

页数：19

共 184 条

[41] Changes in the diffusion of water and intracellular metabolites after excitotoxic injury and global ischemia in neonatal rat brain [J].