A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake

被引:59
作者
Summers, SA
Birnbaum, MJ
机构
[1] UNIV PENN,HOWARD HUGHES MED INST,PHILADELPHIA,PA 19104
[2] UNIV PENN,DEPT MED,PHILADELPHIA,PA 19104
关键词
D O I
10.1042/bst0250981
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:981 / 988
页数:8
相关论文
共 64 条
[41]   Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation [J].
Kohn, AD ;
Summers, SA ;
Birnbaum, MJ ;
Roth, RA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (49) :31372-31378
[42]   INSULIN STIMULATES THE KINASE-ACTIVITY OF RAC-PK, A PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING SER/THR KINASE [J].
KOHN, AD ;
KOVACINA, KS ;
ROTH, RA .
EMBO JOURNAL, 1995, 14 (17) :4288-4295
[43]   REQUIREMENT FOR PHOSPHOINOSITIDE 3-KINASE IN INSULIN-STIMULATED GLUT4 TRANSLOCATION IN 3T3-L1 ADIPOCYTES [J].
KOTANI, K ;
CAROZZI, AJ ;
SAKAUE, H ;
HARA, K ;
ROBINSON, LJ ;
CLARK, SF ;
YONEZAWA, K ;
JAMES, DE ;
KASUGA, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 209 (01) :343-348
[44]   THE RAS SIGNALING PATHWAY MIMICS INSULIN ACTION ON GLUCOSE TRANSPORTER TRANSLOCATION [J].
KOZMA, L ;
BALTENSPERGER, K ;
KLARLUND, J ;
PORRAS, A ;
SANTOS, E ;
CZECH, MP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4460-4464
[45]   MITOGEN-ACTIVATED PROTEIN-KINASE KINASE INHIBITION DOES NOT BLOCK THE STIMULATION OF GLUCOSE-UTILIZATION BY INSULIN [J].
LAZAR, DF ;
WIESE, RJ ;
BRADY, MJ ;
MASTICK, CC ;
WATERS, SB ;
YAMAUCHI, K ;
PESSIN, JE ;
CUATRECASAS, P ;
SALTIEL, AR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (35) :20801-20807
[46]   GRB-IR - A SH2-DOMAIN-CONTAINING PROTEIN THAT BINDS TO THE INSULIN-RECEPTOR AND INHIBITS ITS FUNCTION [J].
LIU, F ;
ROTH, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) :10287-10291
[47]   RAS SIGNALING IN THE ACTIVATION OF GLUCOSE-TRANSPORT BY INSULIN [J].
MANCHESTER, J ;
KONG, XM ;
LOWRY, OH ;
LAWRENCE, JC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4644-4648
[48]   Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes [J].
Martin, SS ;
Haruta, T ;
Morris, AJ ;
Klippel, A ;
Williams, LT ;
Olefsky, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (30) :17605-17608
[49]   Evidence for an insulin receptor substrate 1 independent insulin signaling pathway that mediates insulin-responsive glucose transporter (GLUT4) translocation [J].
Morris, AJ ;
Martin, SS ;
Haruta, T ;
Nelson, JG ;
Vollenweider, P ;
Gustafson, TA ;
Mueckler, M ;
Rose, DW ;
Olefsky, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8401-8406
[50]  
OKADA T, 1994, J BIOL CHEM, V269, P3568