Transgenerational Epigenetic Inheritance: Myths and Mechanisms

被引：1112

作者：

Heard, Edith ^{[1
,2
]}

Martienssen, Robert A. ^{[3
,4
,5
]}

机构：

[1] Inst Curie, CNRS UMR3215, INSERM U934, Mammalian Dev Epigenet Grp, F-75248 Paris 05, France

[2] Coll France, F-75005 Paris, France

[3] Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA

[4] Cold Spring Harbor Lab, Gordon & Betty Moore Fdn, Cold Spring Harbor, NY 11724 USA

[5] Ecole Normale Super, IBENS, Chaire Blaise Pascal, F-75230 Paris, France

来源：

CELL | 2014年 / 157卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

DIRECTED DNA METHYLATION; TRANSPOSABLE ELEMENTS; CAENORHABDITIS-ELEGANS; ARABIDOPSIS-THALIANA; C; ELEGANS; SMALL RNA; RECOMBINATION LANDSCAPE; GERMLINE IMMORTALITY; REPETITIVE ELEMENTS; PRENATAL EXPOSURE;

D O I：

10.1016/j.cell.2014.02.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the human genome was sequenced, the term ``epigenetics'' is increasingly being associated with the hope that we are more than just the sum of our genes. Might what we eat, the air we breathe, or even the emotions we feel influence not only our genes but those of descendants? The environment can certainly influence gene expression and can lead to disease, but transgenerational consequences are another matter. Although the inheritance of epigenetic characters can certainly occur-particularly in plants-how much is due to the environment and the extent to which it happens in humans remain unclear.

引用

页码：95 / 109

页数：15

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