Multi-scale models of local control of calcium induced calcium release

被引：32

作者：

Hinch, R

Greenstein, JL

Winslow, RL ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Ctr Cardiovasc Bioinformat & Modeling, Baltimore, MD 21205 USA

[2] Whiting Sch Engn, Baltimore, MD USA

[3] Brasenose Coll, Oxford OX1 4AJ, England

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2006年 / 90卷 / 1-3期

基金：

英国惠康基金;

关键词：

calcium-induced-calcium-release; CICR; local control theory; excitation-contraction coupling; multi-scale modelling;

D O I：

10.1016/j.pbiomolbio.2005.05.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium-induced-calclum-release in cardiac myocytes is the release of Ca2+ from the sarcoplasmic reticulum (SR) triggered by Ca2+ entering the cell through L-type Ca2+ channels. The Ca2+ is released through ryanodine receptors which 'sense' local [Ca2+] in the small region (the diadic space) positioned between the t-tubules and the SR. The length-scale of a single diad is of the order of 10 nm and the diffusion time-scale is of order of 1 mu s with each cell containing approximately 10,000 diadic spaces which act independently. However, typically one is interested in Ca2+ currents at the whole cell level and higher. This is a multi-scale problem and cannot be solved by direct computation. In this paper we develop a general framework for deriving approximate solutions of these models. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：136 / 150

页数：15