Control of tumor development by intratumoral cytokines

被引：26

作者：

Pages, F

Vives, V

Sautès-Fridman, C

Fossiez, F

Berger, A

Cugnenc, PH

Tartour, E

Fridman, WH

机构：

[1] Inst Curie, INSERM U255, F-75005 Paris, France

[2] Shering Plough, Dardilly, France

[3] Serv Chirurg Gen & Digest, Paris, France

来源：

IMMUNOLOGY LETTERS | 1999年 / 68卷 / 01期

关键词：

cancer; interleukin-17; interferon-gamma; interleukin-18;

D O I：

10.1016/S0165-2478(99)00042-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The local immune reactions may influence the clinical outcome of human tumors. In carcinoma of the cervix, high gene expression of IL6 with tumor invasiveness whereas lack of gene expression of IFN beta is correlated with poor prognosis. In colorectal cancer, lack of expression of IFN beta is associated with the presence of distant metastasis and poor survival. The production of IL17 and IL18, inducers of IL6 and IFN beta respectively is regulated in these tumors and may control the levels of the effector cytokines, i.e. IL6 and IFN beta. The mechanisms by which these cytokines act are linked to the recruitment of effector cells such as macrophages. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：135 / 139

页数：5

共 25 条

[11]

KAKLAMANIS L, 1992, CANCER SURV, V13, P155

[12]

MACHENSEN A, 1993, CANCER RES, V53, P35569

[13]

MOSMANN TR, 1986, J IMMUNOL, V136, P2348

[14]

Niehans GA, 1997, CANCER RES, V57, P1007

[15] The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand [J].

OConnell, J ;

OSullivan, GC ;

Collins, JK ;

Shanahan, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :1075-1082

[16] CLONING OF A NEW CYTOKINE THAT INDUCES IFN-GAMMA PRODUCTION BY T-CELLS [J].

OKAMURA, H ;

TSUTSUI, H ;

KOMATSU, T ;

YUTSUDO, M ;

HAKURA, A ;

TANIMOTO, T ;

TORIGOE, K ;

OKURA, T ;

NUKADA, Y ;

HATTORI, K ;

AKITA, K ;

NAMBA, M ;

TANABE, F ;

KONISHI, K ;

FUKUDA, S ;

KURIMOTO, M .

NATURE, 1995, 378 (6552) :88-91

[17]

OKAMURA H, 1995, INFECT IMMUN, V63, P3672

[18]

PAGES F, 1999, IN PRESS INT J CANC

[19] QUANTITATIVE TITRATION OF NUCLEIC-ACIDS BY ENZYMATIC AMPLIFICATION REACTIONS RUN TO SATURATION [J].

PANNETIER, C ;

DELASSUS, S ;

DARCHE, S ;

SAUCIER, C ;

KOURILSKY, P .

NUCLEIC ACIDS RESEARCH, 1993, 21 (03) :577-583

[20]

ROCHLITZ C, 1999, IN PRESS CANC GENE T

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