Targeting the Lung: Preclinical and Comparative Evaluation of Anticancer Aerosols in Dogs with Naturally Occurring Cancers

被引：30

作者：

Khanna, Chand ^{[1
]}

Vail, David M. ^{[2
,3
]}

机构：

[1] NCI, Ctr Canc Res, Comparat Oncol Program, NIH, Bethesda, MD 20892 USA

[2] Univ Wisconsin, Sch Vet Med, Madison, WI 53706 USA

[3] Univ Wisconsin, Ctr Comprehens Canc, Madison, WI 53706 USA

来源：

CURRENT CANCER DRUG TARGETS | 2003年 / 3卷 / 04期

关键词：

D O I：

10.2174/1568009033481903

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pet dogs with naturally occurring cancers offer a novel opportunity for the study of both cancer biology and therapy. The following review will provide the rationale for the use of these spontaneous cancer models in translational research, particularly in the development of anticancer aerosols. A summary of work involving pet dogs with primary and metastatic cancers to the lung and the investigation of therapeutic chemotherapy and cytokine immunotherapy aerosols will be presented.

引用

页码：265 / 273

页数：9