Synthesis and properties of spiro nucleosides containing the barbituric acid moiety

被引：68

作者：

Renard, A ^{[1
]}

Lhomme, J ^{[1
]}

Kotera, M ^{[1
]}

机构：

[1] Univ Grenoble 1, LEDSS, CNRS, F-38041 Grenoble 9, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 04期

关键词：

D O I：

10.1021/jo016194y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The two chiral spiro nucleosides 4 and 5 containing the barbituric acid moiety were efficiently synthesized from optically pure precursors, and their properties were studied. The carbocyclic nucleoside 5 is considerably more stable against ring opening than the deoxyribosyl derivative 4. Both compounds present enhanced hydrogen bonding capacity with diacetyladenosine.

引用

页码：1302 / 1307

页数：6

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