An efficient synthesis of the phytoestrogen 8-prenylnaringenin from isoxanthohumol with magnesium iodide etherate

被引：33

作者：

Aniol, Miroslaw ^{[1
]}

Szymanska, Katarzyna ^{[1
]}

Zolnierczyk, Anna ^{[1
]}

机构：

[1] Wroclaw Univ Environm & Life Sci, Dept Chem, PL-50375 Wroclaw, Poland

来源：

TETRAHEDRON | 2008年 / 64卷 / 40期

关键词：

xanthohumol; isoxanthohumol; 8-prenylnaringenin; phytoestrogen; demethylation; magnesium iodide etherate;

D O I：

10.1016/j.tet.2008.07.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Xanthohumol was isolated from supercritical carbon dioxide-spent hop and transformed into isoxanthohumol. The demethylation of isoxanthohumol with the best yield 93% occurred when MgI(2) etherate in anhydrous THF was applied. Salts such as MgBr(2), MgCl(2), CaI(2), Mg(OAc)(2), Mg(OMe)(2) were also investigated. A convenient method for the xanthohumol isolation from supercritical carbon dioxidespent hop is also described. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：9544 / 9547

页数：4

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