DIP, the Database of Interacting Proteins:: a research tool for studying cellular networks of protein interactions

被引:906
作者
Xenarios, I [1 ]
Salwínski, L [1 ]
Duan, XQJ [1 ]
Higney, P [1 ]
Kim, SM [1 ]
Eisenberg, D [1 ]
机构
[1] Univ Calif Los Angeles, Inst Mol Biol, UCLA DOE Lab Struct Biol & Mol Med, Los Angeles, CA 90095 USA
关键词
D O I
10.1093/nar/30.1.303
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Database of Interacting Proteins (DIP: http://dip.doe-mbi.ucla.edu) is a database that documents experimentally determined protein-protein interactions. It provides the scientific community with an integrated set of tools for browsing and extracting information about protein interaction networks. As of September 2001, the DIP catalogs similar to11 000 unique interactions among 5900 proteins from >80 organisms; the vast majority from yeast, Helicobacter pylori and human. Tools have been developed that allow users to analyze, visualize and integrate their own experimental data with the information about protein-protein interactions available in the DIP database.
引用
收藏
页码:303 / 305
页数:3
相关论文
共 16 条
[1]   Zip3 provides a link between recombination enzymes and synaptonemal complex proteins [J].
Agarwal, S ;
Roeder, GS .
CELL, 2000, 102 (02) :245-255
[2]   BIND - The Biomolecular Interaction Network Database [J].
Bader, GD ;
Donaldson, I ;
Wolting, C ;
Ouellette, BFF ;
Pawson, T ;
Hogue, CWV .
NUCLEIC ACIDS RESEARCH, 2001, 29 (01) :242-245
[3]   YPD™, PombePD™ and WormPD™:: model organism volumes of the BioKnowledge™ Library, an integrated resource for protein information [J].
Costanzo, MC ;
Crawford, ME ;
Hirschman, JE ;
Kranz, JE ;
Olsen, P ;
Robertson, LS ;
Skrzypek, MS ;
Braun, BR ;
Hopkins, KL ;
Kondu, P ;
Lengieza, C ;
Lew-Smith, JE ;
Tillberg, M ;
Garrels, JI .
NUCLEIC ACIDS RESEARCH, 2001, 29 (01) :75-79
[4]   Genomic expression programs in the response of yeast cells to environmental changes [J].
Gasch, AP ;
Spellman, PT ;
Kao, CM ;
Carmel-Harel, O ;
Eisen, MB ;
Storz, G ;
Botstein, D ;
Brown, PO .
MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (12) :4241-4257
[5]   A relationship between gene expression and protein interactions on the proteome scale:: analysis of the bacteriophage T7 and the yeast Saccharomyces cerevisiae [J].
Grigoriev, A .
NUCLEIC ACIDS RESEARCH, 2001, 29 (17) :3513-3519
[6]   A comprehensive two-hybrid analysis to explore the yeast protein interactome [J].
Ito, T ;
Chiba, T ;
Ozawa, R ;
Yoshida, M ;
Hattori, M ;
Sakaki, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4569-4574
[7]   Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins [J].
Ito, T ;
Tashiro, K ;
Muta, S ;
Ozawa, R ;
Chiba, T ;
Nishizawa, M ;
Yamamoto, K ;
Kuhara, S ;
Sakaki, Y .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (03) :1143-1147
[8]   Lethality and centrality in protein networks [J].
Jeong, H ;
Mason, SP ;
Barabási, AL ;
Oltvai, ZN .
NATURE, 2001, 411 (6833) :41-42
[9]  
MARCOTTE E, 2001, BIOINFORMATICS, V17, P1
[10]   A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae [J].
Newman, JRS ;
Wolf, E ;
Kim, PS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (24) :13203-13208