Synthesis of oligonucleotide derivatives containing pyrene labeled glycerol linkers: Enhanced excimer fluorescence on binding to a complementary DNA sequence

被引：50

作者：

Yamana, K

Takei, M

Nakano, H

机构：

[1] Department of Applied Chemistry, Himeji Institute of Technology, Himeji, Hyogo 671-22

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(97)01358-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a pyrene labeled glycerol linker for multiple internal labeling of oligonucleotides has been described. The oligonucleotide containing two successively incorporated pyrenyl residues exhibits enhanced excimer fluorescence upon hybridization to the complementary DNA segment. (C) 1997 Elsevier Science Ltd.

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页码：6051 / 6054

页数：4

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