Origin of blood cells and HSC production in the embryo

被引：73

作者：

Costa, Guilherme ^{[2
,3
]}

Kouskoff, Valerie ^{[2
]}

Lacaud, Georges ^{[1
]}

机构：

[1] Univ Manchester, Canc Res UK Stem Cell Biol Grp, Inst Canc Res, Manchester M20 4BX, Lancs, England

[2] Univ Manchester, Canc Res UK Stem Cell Hematopoiesis Grp, Paterson Inst Canc Res, Manchester M20 4BX, Lancs, England

[3] Univ Porto, Grad Program Areas Basic & Appl Biol GABBA, P-4100 Oporto, Portugal

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

HEMATOPOIETIC STEM-CELLS; GONAD-MESONEPHROS REGION; MURINE YOLK-SAC; MOUSE EMBRYO; ENDOTHELIAL-CELLS; DEFINITIVE HEMATOPOIESIS; HAEMOGENIC ENDOTHELIUM; AORTIC ENDOTHELIUM; FETAL LIVER; AGM REGION;

D O I：

10.1016/j.it.2012.01.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hematopoietic stem cells (HSCs) are capable of self-renewal and differentiation into all blood cell types. During adult life, they reside in the bone marrow in a quiescent state. By contrast, in the growing embryo hematopoiesis is sequentially found in several developmental niches. This review provides an overview of the still controversial contribution of each of these embryonic sites to the final pool of adult HSCs and discusses new insights into the cellular origin and the molecular regulation implicated in the generation of blood progenitor cells. A better understanding of HSC development during ontogeny is essential to develop new strategies to amplify HSCs or to generate them from embryonic stem cells or by somatic cell reprogramming.

引用

收藏

页码：215 / 223

页数：9

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